Promega Corporation

PPase-2B

PPase-2B is a heterodimeric enzyme composed of a 19kDa calcium-binding subunit and a catalytic subunit (61kDa) that binds calmodulin. PPase-2B was originally identified based on its calcium- and calmodulin-dependent activity toward phosphorylase kinase and inhibitor-1. PPase-2B is identical to the brain protein calcineurin, which constitutes up to 1% of total brain protein. The immunosuppressive drugs FK-506 and cyclosporin A inhibit PPase-2B activity in immune cells, implicating a role for this enzyme in regulation of the immune system. PPase-2B also plays a major role in regulating secretory functions of a varie...

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PPase-2B

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PPase-2B

 Components

  • PPase-2B

    V636A1 x 10u
10u
- V6361 Please Enquire


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Storage Buffer

50mM Tris-HCl (pH 7.0), 50% glycerol.

Storage Conditions

Store at –70°C.

Unit Definition

One unit is the amount of PPase-2B required to release 1nmol of phosphate per minute at 30°C, using p-nitrophenyl phosphate (PNPP) as the substrate.

For product intended use please see Patents & Disclaimers tab.

Use Restrictions

V6361 For Research Use Only. Not for Use in Diagnostic Procedures.

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